منابع مشابه
The mitotic roles of Polo-like kinase.
The Polo-like protein kinases (Plks) are a conserved family of enzymes that play a variety of roles in the passage of cells through M phase (for reviews see Glover et al., 1998; Nigg, 1998). Named after the Drosophila polo gene originally identified through a recessive maternal effect lethal mutation, conserved Plk homologues have been identified in yeast, Xenopus, C. elegans and mammals. The i...
متن کاملRoles of Polo-like Kinase 1 in the Assembly of Functional Mitotic Spindles
BACKGROUND The stable association of chromosomes with both poles of the mitotic spindle (biorientation) depends on spindle pulling forces. These forces create tension across sister kinetochores and are thought to stabilize microtubule-kinetochore interactions and to silence the spindle checkpoint. Polo-like kinase 1 (Plk1) has been implicated in regulating centrosome maturation, mitotic entry, ...
متن کاملRoles of Polo-like kinase 3 in suppressing tumor angiogenesis
Angiogenesis is essential for promoting growth and metastasis of solid tumors by ensuring blood supply to the tumor mass. Targeting angiogenesis is therefore an attractive approach to therapeutic intervention of cancer. Tumor angiogenesis is a process that is controlled by a complex network of molecular components including sensors, signaling transducers, and effectors, leading to cellular resp...
متن کاملMolecular interactions of Polo-like-kinase 1 with the mitotic kinesin-like protein CHO1/MKLP-1.
Polo-like kinases and kinesin-like motor proteins are among the many proteins implicated in the execution of cytokinesis. Polo-like-kinase 1 (Plk1) interacts with the mitotic kinesin-like motor protein CHO1/MKLP-1 during anaphase and telophase, and CHO1/MKLP-1 is a Plk1 substrate in vitro. Here, we explore the molecular interactions of these two key contributors to mitosis and cytokinesis. Usin...
متن کاملThe Small-Molecule Inhibitor BI 2536 Reveals Novel Insights into Mitotic Roles of Polo-like Kinase 1
BACKGROUND The mitotic kinases, Cdk1, Aurora A/B, and Polo-like kinase 1 (Plk1) have been characterized extensively to further understanding of mitotic mechanisms and as potential targets for cancer therapy. Cdk1 and Aurora kinase studies have been facilitated by small-molecule inhibitors, but few if any potent Plk1 inhibitors have been identified. RESULTS We describe the cellular effects of ...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2001
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.114.13.2357